Comparison between ephedrine and noradrenaline in Prevention hypotension after spinal anesthesia in cesarean section: A prospective randomized comparative clinical study

Abstract

Background: Ephedrine and norepinephrine considered an option to maintain maternal blood pressure during spinal anesthesia (SA) since hypotension is considered a common consequence of SA. The aim of the current study is the assessment of the maternal and neonatal safety and efficacy of norepinephrine compared to ephedrine in treatment of SA induced hypotension in cesarian delivery. Patients and Methods: 100 healthy individuals under spinal anesthesia for a cesarean delivery were selected at random to Group N (n = 50). They either got Group E (n = 50) or a 1 mL bolus of intravenous norepinephrine with a density of 10 g/ 1 mL. To maintain their systolic blood pressure, 1 mL of intravenous ephedrine with a density of 5 mg/mL was given to them. The dose of vasopressor boluses used the Apgar score, and maternal hemodynamic elements were all recorded. Results: When compared to Group E, Group N had considerably fewer instances of maternal hypotension, hypertension, and bradycardia and tachycardia. Conclusions: A suitable and safe drug to counteract the hemodynamic effects of spinal anesthesia during cesarean delivery is norepinephrine.