Alcohol Extract Effect of Raw Propolis in Acinetobacter Baumannii Isolated from Diabetic Foot Ulcers

Authors

  • Al-Mashkoor, Huda Mohammed Department of Biology, College of Education for Pure Sciences / University of Kerbala / Kerbala, Iraq.
  • Al-Awade, Hiyame Abdul Ridha Department of Biology, College of Education for Pure Sciences / University of Kerbala / Kerbala, Iraq.

Keywords:

Diabetes Foot, ethanoic propolis Extraction, Diabetes Foot Ulcers, Acinetobacter baumannii, Dermacyn, Antibiotic.

Abstract

Background: Diabetic foot ulcers (DFU) are severe complications of diabetes, often leading to limb amputation due to bacterial infection, such as Acinetobacter baumannii. This study aims to isolate A. baumannii in DFU, assess its sensitivity to alcoholic propolis extract compared to antibiotics, and evaluate its potential as a natural antimicrobial. Methods: Fifty DFU samples from patients at Al-Kafeel Specialty Hospital in Karbala Governorate (September 2022 - February 2023) were cultured and diagnosed with 16 A. baumannii isolates, primarily in males. Results: Crude alcoholic propolis extract inhibited A. baumannii growth in a concentration-dependent manner. The largest inhibition diameter (23.67 mm) was at 150 mg/ml, while the smallest (8.33 mm) was at 12.5 mg/ml. Propolis outperformed Trimethoprim Sulfamethoxazole. Dermacyn extract showed a synergistic effect. MIC was 25 mg/mL, and MBC was 100 mg/ml. Conclusion: Alcoholic propolis extract demonstrates potential as a natural antimicrobial against A. baumannii in DFU infections.

Downloads

Published

2024-12-24

Issue

Vol. 23 No. 1 (2024): Journal of Carcinogenesis Vol 23, Issue 1

Section

Articles