The Effect of Ochratoxin A on kidney function parameters of Patients with Chronic kidney disease in Kerbala

Authors

  • Othaim Razzaq Falayh Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq
  • Sami Abdel Reda Ali Department of Clinical Laboratories, College of Applied Medical Sciences, University of Kerbala, Kerbala, Iraq

Keywords:

CKD, OTA, U, Cr, GFR.

Abstract

Objective: Investigating ochratoxin A (OTA) contamination in various countries and its health risks, particularly in chronic kidney disease (CKD) patients in Karbala, Iraq. Methods: A case-control study conducted from December 2022 to April 2023 assessed OTA exposure in CKD patients and healthy controls in Karbala. OTA levels were measured using thin-layer chromatography and high-performance liquid chromatography. Kidney function parameters were also evaluated. Results: OTA was found in 99% of CKD patients' blood plasma compared to 32% in healthy individuals, with higher prevalence in females (56%) than males (43%). Unidentified CKD cases showed links between OTA exposure, lower GFR, higher urea, and creatinine levels. Conclusion: OTA exposure in CKD patients suggests unidentified toxin sources. Kidney function markers were affected. Further research should investigate underlying causes of CKD rise and broader national impacts.

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Published

2024-02-04

Issue

Vol. 22 No. 2 (2023): Journal of Carcinogenesis Vol 22, Issue 2

Section

Articles